Publikationen Univ.-Prof. Dr. Christian Singer
Bücher und Buchkapitel
Kubista E, Singer CF, Seifert M (2008) Aromatasehemmer in der endokrinen Therapie des Mammakarzinoms. Uni-Med Verlag Publishers, Bremen, in press
Singer CF, Gschwantler-Kaulich D, Fink-Retter A, Kubista E, Czerwenka K and Hudelist G (2006) Significance and Prognostic Value of Estradiol Modulating Enzymes in Breast Cancer. New Research Communications of Tumor Markers (F. Columbus, ed.) Nova Science Publishers, in press
Hudelist G, Czerwenka K, Kubista E, Wieser F, Tschugguel W, and Singer CF (2005) Interleukin-1 System and Sex Steroid Receptor Gene Expression In Human Endometrial Cancer. Ovarian Cancer, New Research (A.P. Bardos, ed.) ISBN 1594542414, Nova Science Publishers
Singer CF, Rasmussen A, Lippman ME, and Cullen KJ (1999) Breast cancer cells influence the pattern of cytokine expression in neighbouring breast fibroblasts via paracrine interactions. Proc. 11th Int. Meeting of the Eur. Soc. Of Gyn. Onc. (Bosze, Maggino, De Oliveira et Onnis, ed.) Monduzzi Editore, 3-7
Kokorine I, Nisolle M, Donnez J, Singer CF, Galant C, Eeckhout Y, Courtoy PJ, and Marbaix E (1999) Matrix Metalloproteinases and endometriosis. Understanding Endometriosis: Proc. VIth Int. World Congr. on Endometriosis, (A. Lemay, ed.) Parthenon Publ. Press, 239-250
Singer C (1987) `Der Plansee - History and Scenary of an Austrian Lake`, ISBN 3-85423-074-5, Steiger Publishing Company, Innsbruck, Austria
Wissenschaftliche Publikationen
Singer CF (2008) Climacteric complaints after breast cancer - Is HRT an option? Breast Care, accepted
Singer CF, Koestler WJ, and Hudelist G (2008) Predicting the efficacy of trastuzumab-based therapy in breast cancer: current standards and future strategies BBA - Reviews on Cancer, in print
Mlineritsch B, Tausch C, Singer C, Luschin-Ebengreuth G, Jakesz R, Ploner F, Stierer M, Melbinger E, Menzel C, Urbania A, Fridrik M, Steger G, Wohlmuth P, Gnant M, Greil R; on behalf of the Austrian Breast, Colorectal Cancer Study Group (ABCSG). Exemestane as primary systemic treatment for hormone receptor positive post-menopausal breast cancer patients: a phase II trial of the Austrian Breast and Colorectal Cancer Study Group (ABCSG-17). Breast Cancer Res Treat. 2007 Dec 22; [Epub ahead of print]
Galid A, Singer CF, Gnant M, Jakesz R, Steger G and Kubista E on behalf of the Austrian Breast and Colorectal Study Group. Effect of 3 vs 6 cycles of primary systemic Epirubicin / Docetaxel on axillary downstaging in women with locally advanced breast cancer, submitted
Rudas M, Lehnert M, Huynh A, Jakesz R, Singer C, Lax S, Schippinger W, Dietze O, Greil R, Stiglbauer W, Kwasny W, Grill R, Stierer M, Gnant MF, Filipits M; for the Austrian Breast and Colorectal Cancer Study Group. Cyclin D1 Expression in Breast Cancer Patients Receiving Adjuvant Tamoxifen-Based Therapy. Clin Cancer Res. 2008 Mar 15;14(6):1767-1774.
Hudelist G, Huber A, Knoefler M, Haider S, Kolbus A, Czerwenka K, Helmy S, Kubista E, and Singer CF (2008) Beta-hCG/LH receptor (b-HCG/LH-R) expression in eutopic endometrium and endometriotic implants: evidence for b-HCG sensitivity of endometriosis, Repr Sciences, accepted
Hudelist G, Wülfing P, Kersting C, Burger H, Mattsson B, Czerwenka K, Kubista E, Gschwantler-Kaulich D, Fink-Retter A, Singer CF. Expression of aromatase and estrogen sulfotransferase in preinvasive and invasive breast cancer. J Cancer Res Clin Oncol. 2008 Jan;134(1):67-73
Hudelist G, Czerwenka K, Keckstein J, Haas C, Fink-Retter A, Gschwantler-Kaulich D, Kubista E, Singer CF. Expression of aromatase and estrogen sulfotransferase (EST) in eutopic and ectopic endometrium - evidence for unbalanced estradiol production in endometriosis (2007) Repr Sciencecs 14(8):798-805
Singer CF, Gschwantler-Kaulich D, Fink-Retter A, Haas C, Hudelist G, Czerwenka K, and Kubista E (2007). Differential Gene Expression Profile in Breast Cancer-derived Stromal Fibroblasts, Breast Cancer Res Treat, Sep 26; [Epub ahead of print]
Hudelist G , Wagner T, Rosner M, Fink-Retter A, Gschwantler-Kaulich D, Czerwenka K, Kroiss R, Tea M, Pischinger K, Köstler WJ, Attems J, Mueller R, Blaukopf C, Kubista E, Hengstschläger M and Singer CF. Intratumoral IGF-1 protein expression is selectively up-regulated in breast cancer patients with BRCA1/2 mutations (2007). Endocrine-Related Cancer 14(4):1053-1062
Huber A, Hudelist G, Auer M, Knöfler M, Saleh L, Hrachowitz C, Huber JC, Czerwenka K, Kubista E and Singer CF. Effect of highly purified hCG preparations on the gene expression signature of stromal cells derived from endometriotic lesions: potential mechanisms for the therapeutic effect of beta-HCG in vivo (2007). Fertil Steril 88:1232-1239
Steger GS, Galid A, Gnant M, Mlineritsch B, Lang A, Tausch C, Rudas M, Greil R, Wenzel C, Singer CF, Haid A, Pöstlberger S, Samonigg H, Luschin-Ebengreuth G, Kwasny W, Klug E, Kubista E, Menzel C, and Jakesz R for the Austrian Breast and Colorectal Cancer Study Group (ABCSG) (2007) Pathologic Complete Response with 6 vs 3 Cycles of Neoadjuvant Epirubicin/Docetaxel plus G-CSF in Operable Breast Cancer: Results of ABCSG –14 (2006), J Clin Oncol 25 (15): 2012-2018
Gschwantler-Kaulich D, Fink-Retter A, Hudelist G, Bachrich T, Ledesma M, Ruecklinger E, Kubista E and Singer CF. Efficacy of primary systemic chemotherapy regimen containing anthracyclines with/without taxanes in comparison to CMF in women with early breast cancer (2007) J. Chemother 19(6):731-738
Kubista E, Planellas-Gomez JVM, Dowsett M, Foidart JM, Pohlodek K, Serreyn R, Nechushkin M, Manikhas AG, Semiglazov VF, Hageluken CCM, and Singer CF. Effect of Tibolone on Breast Cancer Cell Proliferation in postmenopausal ER+ patients: Results from a double-blind, placebo-controlled, randomized Clinical Trial (STEM) (2007). Clin Cancer Res 13 (14): 4185-90
Hudelist G, Wülfing P, Kersting C, Burger H, Mattsson B, Czerwenka K, Kubista E, Gschwantler-Kaulich D, Fink-Retter A, Singer CF. Expression of aromatase and estrogen sulfotransferase (EST) in preinvasive and invasive breast cancer (2007). J Cancer Res Clin Oncol 134(1):67-73
Singer CF and Ruhnke G. Breast Cancer Screening: Where are we? Where should we go? How do we get there?, submitted
REICH O, HUDELIST G AND SINGER CF ESTROGEN SULPHOTRANSFERASE EXPRESSION IN ENDOMETRIAL STROMAL SARCOMAS: AN IMMUNOHISTOCHEMICAL STUDY (2006) PATHOLOGY - RESEARCH AND PRACTICE,203 (2): 85-87
SINGER CF, FINK-RETTER A, GSCHWANTLER-KAULICH D, THALHAMMER T, HUDELIST G, MUELLER R, CZERWENKA K AND KUBISTA E SELECTIVE SPATIAL UP-REGULATION OF INTRATUMORAL STROMAL AROMATASE IN BREAST CANCER PATIENTS: EVIDENCE FOR IMBALANCE OF LOCAL ESTROGEN METABOLISM (2006)ENDOCRINE-RELATED CANCER, 13: 1101-1107
Fink-Retter A, Gschwantler-Kaulich D, Hudelist G, Mueller R, Kubista E, Czerwenka K and Singer CF Differential spatial expression and activation pattern of EGFR and HER2 in human breast cancer (2007). Oncology Reports, 18 (2): 299-304
Singer CF, Hudelist G, Gschwantler-Kaulich D, Fink-Retter A, Mueller R, Walter I, Czerwenka K and Kubista E Interleukin-1 alpha protein secretion in breast cancer is associated with poor differentiation and estrogen receptor alpha negativity (2006) Int J Gynecol Cancer 16, Suppl 2: 556-559
Hudelist G, Singer CF, Pischinger K, Kaserer K, Manavi M, Kubista E, Czerwenka K Proteomic Analysis in Human Breast Cancer: Identification of a Characteristic Protein Expression Profile of Malignant Breast Epithelium (2006) Proteomics, 6: 1989 -2002
Singer CF and Hudelist G, Walter I, Rueckliniger E, Czerwenka K, Kubista E and Huber AV Tissue array-based expression of transglutaminase-2 in human breast and ovarian cancer (2006) Clin & Experiment Metastasis, 23(1):33-9
Gschwantler-Kaulich D, Fink-Retter A, Kubista E and Singer CF (2006) Prädiktive Onkologie. Gyn-Aktiv 1/06: 23-25
Langer S, Singer CF, Hudelist G, Dampier B, Kaserer K, Vinatzer U, Pehamberger H, Zielinski CC, Kubista E and Schreiber M Jun and Fos family protein expression in human breast cancer: Correlation of protein expression and clinicopathological parameters (2006) Europ J Gynecol Oncol, 27(4): 345-352)
Singer CF, Hudelist G, Lamm W, Mueller R, Handl C, Kubista E and Czerwenka K (2006) Active (p)CrkL is overexpressed in human malignancies: potential role as a surrogate parameter for therapeutic tyrosine kinase inhibition, Oncology Reports 15(2): 353-9.
Gschwantler-Kaulich D, Fink-Retter A, Kubista E and Singer CF (2006) Kosteneffektivität von Herceptin. Gyn-Aktiv 1/06: 20-21
Köstler WJ, Hudelist G, Rabitsch W, Czerwenka K, Müller R, Singer CF and Zielinski CC (2006) Insulin-like growth factor-I receptor (IGF-IR) expression does not predict for resistance to trastuzumab-based treatment in patients with Her-2/neu overexpressing metastatic breast cancer, J Canc Res Clin Oncol 132(1): 9-18
Hudelist G and Köstler WJ, Czerwenka K, Kubista E,Attems J, Müller R, Gschwantler-Kaulich D, Manavi M, Huber I, Hoschützky H, Zielinski CC and Singer CF (2006) Her-2/neu and EGFR tyrosine kinase activation predict the efficacy of trastuzumab-based therapy in patients with metastatic breast cancer. Int J Cancer, 118(5):1126-34
Hudelist G, Köstler WJ, Gschwantler-Kaulich D, Czerwenka K, Kubista E, Müller R, Helmy S, Manavi M, Zielinski CC and Singer CF (2006) Serum EGFR levels and efficacy of trastuzumab-based therapy in patients with metastatic breast cancer. Europ J Cancer, 42(2):186-92
Hudelist G, Keckstein J, Czerwenka K, Lass H, Walter I, Auer M, Wieser F, Wenzl R, Kubista E and Singer CF (2005) Estrogen receptor beta and matrix metalloproteinase-1 are co-expressed in uterine endometrium and endometriotic lesions of patients with endometriosis. Fertil Steril, 84 Suppl 2:1249-56
Hudelist G, Singer CF and Keckstein J (2005) Matrix-Metalloproteinasen (MMPs) und deren Bedeutung für die Menstruation und Endometriose. Zentralbl Gynakol 127: 318-322
Singer CF (2005) Herceptin – adjuvante Therapie des Mammakarzinoms. Ein neuer Standard.Gyn-Aktiv 5: 14-16
Hudelist G, Keckstein J, Czerwenka K, Lass H, Walter I, Auer M, Wieser F, Wenzl R, Kubista E, and Singer CF (2005) Estrogen receptor and matrix metalloproteinase 1 are co-expressed in uterine endoemtrium and endometriotic lesions of patients with endometriosis. Fertil Steril, 84 Suppl 2:1249-56
Gschwantler-Kaulich D, Fink A, Kubista E and Singer CF (2005) Predictive Oncology. Senologie, accepted
Hudelist G, Singer CF, Kubista E, and Czerwenka K (2005) Use of high-throughput arrays for profiling differentially expressed proteins in normal and malignant tissues. Anticancer Drugs16(7): 683-689
Gschwantler-Kaulich D, Hudelist G, Koestler WJ, Czerwenka K, Mueller R, Ruecklinger E, Kubista E and Singer CF (2005) EGFR activity in HER-2 over-expressing metastatic breast cancer: evidence for simultaneous phosphorylation of Her-2/neu and EGFR. Oncology Reports14(2): 305-11
Hudelist G, Lass H, Keckstein J, Walter I, Wieser F, Wenzl F, Mueller R, Czerwenka K, Kubista E, and Singer CF (2005) Interleukin 1 alpha (IL1a) and tissue-lytic matrix metalloproteinase-1 (MMP-1) are elevated in ectopic endometrium of patients with endometriosis. Human Reproduction 20(6): 1695-701
Singer CF and Kubista E (2005) Prädiktive Onkologie. Speculum – Zeitschrift für Gynäkologie und Frauenheilkunde 23 (1): 9-11
Koestler WJ, Brodowicz T, Hudelist G, Rudas M, Horvat R, Steger GG, Singer CF, Attems J, Rabitsch W, Fakhrai N, Elandt K, Wiltschke C, Hejna M, and Zielinski CC (2005) The Efficacy of Trastuzumab in Her-2/neu Overexpressing Metastatic Breast Cancer is Independent from p53 Status. J Cancer Research and Clinical Oncology 131(7): 420-428
Singer CF (2005) Herzeptintherapie – Neue Indikationen? GYN-AKTIV, accepted
Koestler W, Steger GG, Krainer M, Kornek G, Locker G, Brodowicz T, Marosi C, Singer CF, Hudelist G, Rabitsch W, Wiltschke C, and Zielinski CC (2005) Single Agent Trastuzumab versus Trastuzumab plus Cytotoxic Chemotherapy in Metastatic Breast Cancer: A single Institution Experience. Anticancer Drugs 16(2):185-90
Hudelist G, Gellen J, Singer CF, Ruecklinger E, Czerwenka K, Kandolf O, and Keckstein J (2005) Occurrence and risk factors predicting severe perineal trauma during childbirth in a referral hospital: role of assisted vaginal delivery. American Journal of Obstetrics and Gynecology 193:875-881
Huber A, Hudelist G, Czerwenka K, Husslein P, Kubista E, and Singer CF (2005) Cervical effacement is associated with a characteristic gene expression profile in the cDNA Array analysis of cervical biopsies American Journal of Obstetrics and Gynecology, 105(1): 91-98
Hudelist G, Czerwenka K, Singer CF, Pischinger K, Kubista E, and Manavi M (2005) Cytobrush-collected malignant cervical epithelial cells display a cancer-specific gene expression pattern in cDNA Array analysis. Cancer Genetics and Cytogenetics 158,1:35-42
Huber AV, Huber CJ, Kolbus A, Martin Imhof M, Nagele F, Loizou D, Kaufmann U, and Singer CF (2004) Effects of Systemic HCG Treatment on Patients with Endometriosis: a New Perspective for a Painful Disease. Wien Klin Wochenschr 116 (24): 839-843
Singer CF, Hudelist G, Lamm W, Mueller R, Czerwenka K, and Kubista E (2004) Expression of membrane-associated tyrosin kinases in human malignancies as potential targets for kinase-specific inhibitors. Endocrine Related Cancer 11(4): 861-869
Hudelist G, Singer CF, Kubista E, Mueller R, and Czerwenka K (2004) Nanobacteria - a possible cause for the development of psammoma bodies in ovarian cancer. Histopathology 45: 633-637
Hudelist G, Pacher M, Singer CF, Holper T, Kubista E, Schreiber M, Manavi M, Bilban M, and Czerwenka K (2004) Use of high-throughput protein arrays for profiling of differentially expressed proteins in normal and malignant breast tissue. Breast Cancer Research and Treatment, 86(3): 283-293
Grunt TW, Singer CF, and Solca F (2004) Disease Models of Cancer: HER2 And Breast Cancer, Drug Discovery Today: Disease Models 1 (1): 17-23
Hudelist G, Koestler W, Czerwenka K, Kubista E, and Singer CF (2004) Predicting the clinical course of breast cancer patients undergoing trastuzumab-based therapy: an outlook, Methods Find Exp Clin Pharmacol. 26 (3): 201-210
Koestler WJ, Steger GG, Soleiman A, Schwab B, Singer CF, Tomek S, Brodowicz T, Krainer M, Wiltschke C, Horvat R, Jakesz R, and Zielinski CC (2004) Monitoring of Serum Her-2/neuPredicts Histopathologic Response to Neoadjuvant Trastuzumab-based Therapy for Breast Cancer, Anticancer Research, 24: 1127-1130
Singer CF, Mogg M, Koestler W, Marton E, Pacher M, Kubista E, and Schreiber M (2004) IGF-1 and IGF-2 Serum Concentrations in Patients with Benign and Malignant Breast Lesions: Free IGF-2 is Correlated with Breast Cancer Size. Clinical Cancer Res 10: 4003-4009
Hudelist G, Manavi M, Pischinger KI, Watkins-Riedel T, Singer CF, Kubista E, and Czerwenka KF (2004) Physical state and expression of HPV DNA in benign and dysplastic cervical tissue: different levels of viral integration are correlated with lesion grade. Gynecol Oncol 92(3): 873-880
Koestler WB, Schwab B, Singer CF, Neumann R, Rücklinger E, Marton E, Brodowicz T, Tomek S, Hejna M, Steger G, Krainer M, Wiltschke C, and Zielinski CC (2004) Monitoring of Serum Her-2/neu predicts Response and Progression-free Survival to Trastuzumab in Patients with Metastatic Breast Cancer, Clinical Cancer Res 10: 1618-1624
Asseryanis, E, Ruecklinger, E, Hellan, M, Kubista, E and Singer CF (2004) Breast Cancer Size is correlated with body mass index and androgen serum levels. Gynecological Endocrinology 18 (1): 29-36
Singer CF, Kronsteiner N, Hudelist G., Marton E, Walter I, Kubista M, Czerwenka, K, Schreiber M, Seifert M, and Kubista E (2003) IL-1 system and sex steroid receptor expression in human breast cancer: IL-1alpha protein secretion is correlated with malignant phenotype, Clinical Cancer Res 9: 4877-4883
Hudelist G, Kostler WJ, Attems J, Czerwenka K, Muller R, Manavi M, Steger GG, Kubista E, Zielinski CC, and Singer CF (2003) Her-2/neu-triggered intracellular tyrosine kinase activation: in vivo relevance of ligand-independent activation mechanisms and impact upon the efficacy of trastuzumab-based treatment. Br J Cancer 89: 983-991
Hudelist G, Singer CF, Manavi M, Pischinger K, Kubista E, Czerwenka K (2003) Co-expression of ErbB-family members in human breast cancer: Her-2/neu is the preferred dimerization candidate in nodal-positive tumors. Breast Cancer Res Treat 80: 353-361
Koestler WJ, Amann G, Grunt TW, Singer CF, Schneider SM, Brodowicz T, Tomek S and Zielinski CC. (2003) Recurrent Malignant Triton Tumour - First report on a long time survivor, Oncology Reports 10(3): 533-535
Hudelist G, Czerwenka K, Kubista E, Marton E, Pischinger K, and Singer CF (2003) Expression of Sex Steroid Receptors and their Co-factors in Normal and Malignant Breast Tissue: AIB1 Is a Carcinoma-Specific Co-Activator, Breast Cancer Research and Treatment 78 (2): 193-204
Singer CF, Hudelist G, Schreiber M, and Kubista E (2003) Pharmacological modulation of IGF concentrations as a therapeutical approach in controlling the size of malignant breast tumors, Drugs Today 39 (2): 115-125
Jelincic D, Hudelist G, Singer CF, Bauer M, Horn LC, Bilek K, and Czerwenka K (2003) Klinisches und pathologisches Profil gestationsbedingter Trophoblast-tumoren. Wiener Klinische Wochenzeitschrift 115 (1-2): 29-35
Wieser F, Schneeberger C, Hudelist G, Singer C, Kurz C, Nagele F, Gruber C, Huber JC and Tschugguel W. (2002) Endometrial nuclear receptor co-factors SRC-1 and N-CoR are increased in Human Endometrium during menstruation, Molecular Human Reproduction, 8 (7): 644-650
Singer CF, Kronsteiner N, Marton E, Walter I, Kubista M, Czerwenka K, Schreiber M, Tschugguel W, Wieser F, Kubista E (2002) IL-1alpha gene expression in human endometrial cancer is independent of ovarian steroid receptor expression. Eur J Cancer 38(Suppl 6): 76-77
Hirtenlehner K, Pec M, Kubista E, and Singer CF (2002) Extracellular Matrix Proteins influence phenotype and cytokine expression of human breast cancer cell lines, Eur Cytokine Netw 13: 234-240
Hirtenlehner K, Pec M, Kubista E, and Singer CF (2002) Influence of stroma-derived growth factors on the cytokine expression pattern of human breast cancer cell lines Archives of Gynecology and Obstetrics 266 (2): 108-13
Singer CF, Kronsteiner N, Marton E, Walter I, Kubista M, Czerwenka K, Schreiber M, Tschugguel W, Wieser F, and Kubista E (2002) IL-1 system and sex steroid receptor gene expression in human endometrial cancer, Gynecol Oncol 85 (3): 423-430
Singer CF, Kronsteiner N, Marton E, Kubista M, Cullen, KJ, Hirtenlehner K, Seifert M, and Kubista E (2002) MMP-2 and MMP-9 expression in breast cancer-derived human fibroblasts is differentially regulated by stromal-epithelial interactions, Breast Cancer Res. and Treat. 72 (1): 69-77
Henriet P, Cornet P, Lemoine P, Singer CF, Courtoy PJ, Eeckhout Y, and Marbaix E (2002) Circulating sex hormones and endometrial matrix metalloproteinases (MMPs), Annals N.Y. Acad. Sci. 955: 119-139
Obwegeser R, Berghammer P, Rodrigues M, Granegger S, Hohlagschwandtner M, Kucera H, Singer C, Berger A, Kubista E, and Sinzinger H (1999) A head-to-head comparison between 99M-Tc-Tetrofosmin and 99M-Tc-MIBI scintigraphy to evaluate suspicious breast lesions. Eur. J. Nucl. Med., 26, 1553-1559
Singer CF, Marbaix E, Lemoine P, Eeckhout Y, and Courtoy PJ (1999) Interleukin-1 receptor-ligand interactions modulate interstitial collagenase-1 production by human endometrial fibroblasts. Mol. Hum. Reprod., 5, 240-245
Singer CF, Marbaix E, Lemoine P, Courtoy PJ, and Eeckhout Y (1999) Local cytokines regulate the expression of selected matrix metalloproteinases but not of their tissue inhibitors in human endometrial fibroblasts. Eur. J. Biochem., 259, 40-49
Peeters-Joris C, Hammami K, and Singer CF (1998) Differential regulation of MMP-13 (collagenase-3) and MMP-3 (stromelysin-1) in mouse calvariae, Biochimica Biophysica Acta, (1405) 1-3, 14-28
Marbaix E, Kokorine I, Singer CF, Galant C, Moulin P, Lemoine P, Donnez J, Courtoy P, and Eeckhout Y (1998) La collagenase interstitielle et d`autres metalloproteinases matricielles apparentees declenchent la menstruation. Reproduction humaine et hormones, 11, 159-167
Singer CF, Marbaix E, Kokorine I, Lemoine P, Donnez J, Eeckhout Y, and Courtoy P (1997) Paracrine stimulation of interstitial collagenase (MMP-1) in the human endometrium by interleukin-1a and its dual block by ovarian steroids. Proc. Natl. Acad. Sci. USA, 94, 10341-10345
Singer CF, Rasmussen A, Lippman ME, and Cullen KJ (1997) Coexpression of Stromelysin-3 and Insulin-Like-Growth Factor II in Tumors of Ectodermal, Mesodermal, and Endodermal Origin: Indicator of a Fetal Cell Phenotype. J. Clin. Endocrin. & Metab., 82, 1917-1922
Singer C, Rasmussen A, Smith HS, Lippman ME, Lynch HAT, and Cullen KJ (1995) Malignant Breast Epithelium Selects for Insulin-like Growth Factor II Expression in Breast Stroma: Evidence for Paracrine Function. Cancer Res. 55, 2448-2454
Ellis MJ, Singer C, Hornby A, Rasmussen A, and Cullen KJ (1994) Insulin-like growth factor mediated stromal-epithelial interactions in human breast cancer. Breast Cancer Res. and Treat. 31, 249-261
Cullen KJ, Allison AA, Martire I, Ellis M, and Singer C (1992) Insulin-Like Growth Factor Expression in Breast Cancer Epithelium and Stroma. Breast Cancer Res. and Treat. 22, 21-29
Selected Abstracts und Presentations
Pfeiler G, Wülfing P, Hudelist G, Singer CF and Kubista E. (2008) Loss of LH/HCG receptor expression in invasive breast cancer tissue compared to preinvasive components. Climacteric 11, Supplement 2, Abstract PS-18
Singer CF, Visser M, Coelingh Bennink HJT, Kubista E (2008) The possible role of the fetal SERM estetrol in the treatment of breast cancer. Climacteric 11, Supplement 2, Abstract SS-4-03
Singer C, Kuter I, Hegg R, Badwe R, Harbeck N, Bines J and Lowe E. (2008) NEWEST: a Phase II, randomised, neoadjuvant trial comparing fulvestrant 500 mg vs 250 mg in postmenopausal women with locally advanced, oestrogen receptor-positive (ER+) breast cancer. European Journal of Cancer Supplements Vol 6, No 7, Abstr. 227
Fink-Retter A, Gschwantler-Kaulich D, Hudelist G, Singer CF, Pischinger K, Manavi M and Czerwenka K (2008). Proteomics in mammary cancer research. European Journal of Cancer Supplements Vol 6, No 7, Abstr. 104
Singer C., Gschwantler-Kaulich D., Fink-Retter A., Haas c. , Hudelist G., Czerwenka K., Kubista E. Differential gene expression profile in breast cancer-derived stromal fibroblasts Jahrestagung der Österreichischen u. Bayrischen Gesellschaft fuer Gynaekologie u. Geburtshilfe, Muenchen 7.-9.6.2007 Speculum, Heft 3, Abstractband Jahrestagung
A. Fink-Retter, D. Gschwantler-Kaulich, Hudelist G., K. Czerwenka, E. Kubista, C. Singer. Die Expression von Matrixmetalloproteinasen (MMP1, 2, 9 und 11) in Lymphknotenmetastasen von Brustkrebspatientinnen. Jahrestagung der Österreichischen u. Bayrischen Gesellschaft fuer Gynäkologie u. Geburtshilfe, München 7.-9.6.2007 Speculum, Heft 3, Abstractband Jahrestagung (Poster)
G. Hudelist, K. Czerwenka, J. Keckstein, A. Fink-Retter, D. Gschwantler-Kaulich, E. Kubista, C. Singer. Aromatase und Östrogen-Sulfotransferase (EST) Expression bei Endometriosepatientinnen – Hinweis für unbalancierte und autonome Östrogenproduktion in Endometrioseherden. Jahrestagung der Österreichischen u. Bayrischen Gesellschaft fuer Gynaekologie u. Geburtshilfe, Muenchen 7.-9.6.2007 Speculum, Heft 3, Abstractband Jahrestagung (Poster)
Fink-Retter A., G. Hudelist, R. Mueller, E. Kubista, D. Gschwantler-Kaulich, K. Czerwenka, C. Singer Expression of MMPs 1,2,9 and 11 in breast cancer and metastatic lymph node tissue Joint Meeting of the Austrian and Slovenian Society od Senology Graz, Austria, 13.-15.09.2007
C. Singer, D. Gschwantler-Kaulich, A. Fink-Retter, G. Hudelist, C. Haas, K. Czerwenka, E. Kubista. Differential gene expression profile in breast cancer-derived stromal fibroblasts Joint Meeting of the Austrian and Slovenian Society od Senology Graz, Austria, 13.-15.09.2007
Singer CF, Manavi M, Pischinger K, Kubista E, Czerwenka K: Co-expression of ErbB family members in human breast cancer: Her-2/neu is the preferred dimerization candidate in nodal-positive tumors, ASCO Annual Meeting 2004, New Orleans, 5.-8. Juni 2004
Hudelist G, Singer CF, Manavi M, Pischinger K, Kubista E, Czerwenka K: Co-expression of ErbB family members in human breast cancerActive Her-2/neu signal transduction in breast cancer – relevance of a ligand-independent activation mechanism and impact on the efficacy of trastuzumab-based treatment, ASCO Annual Meeting 2004, New Orleans, 5.-8. Juni 2004
Hudelist G, Singer CF, Manavi M, Pischinger K, Kubista E, Czerwenka K: Co-expression of ErbB family members in human breast cancer: Her-2/neu is the preferred dimerization candidate in nodal-positive tumors, 24. Jahrestagung der Deutschen Gesellschaft für Senologie, 2.-4 September 2004, Freiburg Poster; Onkologie 2004; 26(suppl 2):27, S.55.
Hudelist G, Singer CF, Manavi M, Pischinger K, Kubista E, Czerwenka K: Co-expression of ErbB family members in human breast cancer: Her-2/neu is the preferred dimerization candidate in nodal-positive tumors, Gemeinsame Jahrestagung der Österreichischen und Schweizerischen Gesellschaft für Senologie, 23.-25 September 2004, Basel
Hudelist G, Pacher M, Singer CF, Schreiber M, Kubista E, Bilban M, Czerwenka K. Profiling of differentially expressed proteins in normal and malignant breast tissue by high-throughput antibody microassay – a pilot study 88. Jahrestagung der Deutschen Gesellschaft für Pathologie, 2.-5. Juni 2004, Rostock. Pathology Research and Practic, Abstracts/Symposium Breast Pathology/Pathology 200 (2004) 299-302.
Hudelist G, Gellen J, Singer CF, Kandolf O, Keckstein J. Risikofaktoren für das Auftreten schwerer Dammverletzungen während vaginaler Geburten – eine retrospektive Analyse von 5377 vaginalen Geburten am LKH Villach Speculum Sonderheft 1/2004, 22. Jahrgang, S.41-42 Abstracts der Jahrestagung der OEGGG
Singer CF, Hudelist G, Lamm W, Mueller R, Czerwenka K, Kubista E: Expression of membrane-associated tyrosin kinase in human malignancies as potential targets for kinase-specific inhibitors. Speculum Sobderheft 1/2004, 22. Jahrgang, S.30 Abstracts der Jahrestagung der OEGGG Gemeinsame Jahrestagung der Österreichischen und Schweizerischen Gesellschaft für Senologie, 23.-25 September 2004, Basel Poster; European Surgery, Abstractbande der Jahrestagung 2004
Singer CF, Hudelist G, Kubista E: IGF-1 and IGF-2 serum concentrations in patients with benign and malignant breast lesions: free IGF-2 is correlated with breast cancer size Gemeinsame Jahrestagung der Österreichischen und Schweizerischen Gesellschaft für Senologie,23.-25 September 2004, Basel, Poster; European Surgery, Abstractbande der Jahrestagung 2004
Singer CF Active Her-2/neu signal transduction in breast cancer – relevance of a ligand-independent activation mechanism and impact on the efficacy of trastuzumab-based treatment Int Journal of Molecular Medicine, Vol 14, Supp 1, Abstr 382
Singer CF Expression of phospho-CrkL in human malignomas identifies potential targets for imatinib treatment. Int Journal of Molecular Medicine, Vol 14, Supp 1, Abstr 383
Singer CF IL-1 System and its role in maintaining a malignant phenotype of breast cancer. Endocrine Treatment and Prevention of Breast and Gynecological Cancers, Flemish Gynaecological Oncology Group Annual Meeting, Brussels, Belgium, 15.-17. Jan 2004
Singer CF IL-1 System and sex steroid receptor expression in human breast cancer: IL-1alpha protein secretion is correlated with malignant phenotype” 15th International Congress on Anticancer treatment, 9.-12. Februar 2004
Hudelist G, Singer CF, Manavi M, Pischinger K, Kubista E, and Czerwenka K: Co-expression of ErbB family members in human breast cancer: Her-2/neu is the preferred dimerization candidate in nodal-positive tumors, Wintertagung der Gesellschaft für Ärzte 2003, Billrothhaus Wiener Klinische Wochenschrift Abstract book
Hudelist G, Singer CF, Manavi M, Pischinger K, Kubista E, and Czerwenka K: Co-expression of ErbB family members in human breast cancer: Her-2/neu is the preferred dimerization candidate in nodal-positive tumors 19th European Congress of Pathology, Ljubljana, Slovenia, September 6-11, 2003 Virchows Archiv, Vol 443 (3):297 P-006
Köstler W, Brodowicz T, Hudelist G, Tomek S, Hejna M, Krainer M, Singer CF, Grunt T, Steger G, Wiltschke C and Zielinski CC. Predictive value of p53 status on the outcome of patients treated with trastuzumab 94th Annual Meeting of the American Association for Cancer Research 5.-9. April 2003, Ontario, Canada, 2003, Proceedings, Volume 44, pp921, Abstract #402
Hudelist G, Köstler W, Attems J, Czerwenka K, Müller R, Manavi M, Kubista E, Singer CF: Correlation of Her-2/neu triggered intracellular tyrosine kinase activation with soluble Her-2/neu levels in patients treated with trastuzumab Proceedings of the 94th Annual Meeting of the American Association for Cancer Research, Volume 44, pp509, Abstract # 2237 Poster 5.-9. April 2003, Ontario, Canada, 2003
Singer CF, Kronsteiner N, Hudelist G, Marton E, Walter I, Kubista M, Czerwenka K, Schreiber M, Seifert M, Kubista E: IL-1 system and sex steroid receptor expression in human breast cancer: IL-1alpha protein expression is correlated with malignant phenotype. Proceedings of the 94th Annual Meeting of the American Association for Cancer Research, Volume 44, pp1423, Abstract #6214, 5.-9. April 2003, Ontario, Canada, 2003, Poster
Singer CF, Kronsteiner N, Hudelist G, Marton E, Walter I, Kubista M, Czerwenka K, Schreiber M, Seifert M, Kubista E:IL-1 system and sex steroid receptor expression in human breast cancer: IL-1alpha protein expression is correlated with malignant phenotype. 13th International Meeting of the European Society of Gynecological Oncology 6.-10. April 2003, Brussels, Belgium. Abstracts- International Journal of GynecologicalCancer 13 (Suppl. 1), pp.82
Singer CF, Kronsteiner N, Hudelist G, Marton E, Walter I, Kubista M, Czerwenka K, Schreiber M, Seifert M, Kubista E:IL-1 system and sex steroid receptor expression in human breast cancer: IL-1alpha protein expression and malignant phenotype 23. Jahrestagung der Deutschen Gesellschaft für Senologie 19.-21. Juni 2003, München Onkologie 2003; 26(suppl 2): 74
Singer CF, Kronsteiner N, Hudelist G, Marton E, Walter I, Kubista M, Czerwenka K, Schreiber M, Seifert M, Kubista E:IL-1 system und Sex steroid Rezeptor Expression in humanem Brustkrebs: IL-1alpha protein expression korreliert mit dem malignen Phynotyp Jahrestagung der österreichischen Gesellschaft für Senologie und Schwerpunktsymposium der Arbeitsgemeinschaft Chirurgische Onkologie, Wien, 25.-27.9. 2003 – Vortrag European Surgery, Vol 35, Suppl.192:14 – A45
Hudelist G, Singer CF, Pischinger K, Kubista E, Manavi M, and Czerwenka K: Identification of differentially expressed genes by cDNA array analysis of normal and malignant cervical lavage samples. 13th International Meeting of the European Society of Gynecological Oncology Abstracts- International Journal of Gynecological Cancer 13(Suppl.1) pp.33 6.-10. April 2003, Brussels, Belgium.
Hudelist G, Singer CF, Pischinger K, Kubista E, Manavi M, and Czerwenka K: Identification of differentially expressed genes by cDNA array analysis of normal and malignant cervical lavage samples. 19th European Congress of Pathology, Ljubljana, Slovenia, September 6-11, 2003 Virchows Archiv, Vol 443 (3):313 P-054
Hudelist G, Pacher-Zavisin M, Singer CF, Schreiber M, Kubista E, Manavi M, Bilban M, Czerwenka K Antibody Microarrays: vergleichende Expressionsanalyse von 380 Proteinen in normalen und malignen Gewebsproben der Mamma – eine Pilotstudie. Sommertagung der Gesellschaft für Ärzte 2003, Billrothhaud Wiener Klinische Wochenschrift, Abstract book
Hudelist G, Koestler W, Attems J, Czerwenka K, Müller R, Manavi M, Kubista E, Zielinski CC, Singer CF Proteolytische Abspaltung der extrazellulären Domäne (ECD) als Liganden.unabhängiger Aktivierungsmechanismus des Her-2/neu Rezeptors bei Mammakarzinompatientinnen unter Trastuzumab 23. Jahrestagung der Deutschen Gesellschaft für Senologie, 19.-21. Juni 2003, Munich Onkologie 2003; 26(suppl 2):71
Hudelist G, Koestler W, Attems J, Czerwenka K, Müller R, Manavi M, Kubista E, Zielinski CC, Singer CF Proteolytische Abspaltung der extrazellulären Domäne (ECD) als Liganden.unabhängiger Aktivierungsmechanismus des Her-2/neu Rezeptors bei Mammakarzinompatientinnen unter Trastuzumab Jahrestagung der österreichischen Gesellschaft für Senologie und Schwerpunktsymposium der Arbeitsgemeinschaft Chirurgische Onkologie, Wien, 25.-27.9. 2003 – Vortrag European Surgery, Vol 35, Suppl.192:7 – A20 Geburtshilfe und Frauenheilkunde, 2003, 63:Abstractband, S.924
Singer CF, Kubista E, Garmroudi F, and Cullen KJ. The tumor and its environment: role of local feedback mechanisms in human breast cancer Hungarian Journal of Gynecological Oncology, 7, 173, 2002
Hudelist G, Czerwenka K, Kubista E, Marton E, Pischinger K, Singer CF. Expression of Sex Steroid receptors and their Co-factors in Normal and Malignant Breast Tissue: AIB-1 is a Carcinom-Specific Marker:. Eur. Surg. 34, Supp 186, 4, 2002
Singer CF, Mogg M, Koestler W, Marton E, Pacher M, Kubista E, Schreiber M. IGF-1 and IGF-2 Serum Concentrations in Patients with Benign and Malignant Breast Lesions: Free IGF-2 is Correlated with Breast Cancer Size. Eur. Surg. 34, Supp 186, 5, 2002
Hudelist G, Singer CF, Kronsteiner N, Marton E, Czerwenka K, Walter I, Kubista E, Schreiber M, Seifert M, Kubista E. Die Expression von interleukin-1alpha und beta als Indikator fuer die maligne Potenz des Mammakarzinoms.. Gynäkol Geburtshilfliche Rundschau, 42, 28-29, 2002
Singer CF, Mogg M, Koestler W, Marton E, Pacher M, Kubista E, Schreiber M. IGF-1 and IGF-2 serum concentrations in patients with benign and malignant breast cancer: free IGF-2 is correlated with breast tumor size. European Journal of Cancer, 38, Suppl. 3, S 54, 2002
Köstler WJ, Schwab B, Singer CF, Neumann R, Marton E, Brodowicz T, Tomek S, Steger G, Wiltschke C, Krainer M, Zielinski CC. Pedictive value of serum Her-2/neu ECD during trastuzumab-based therapy in patients with breast cancer. European Journal of Cancer, 38, Suppl. 3, S 109, 2002
Hudelist G, Singer CF, Marton E, Pischinger K, Czerwenka K, Kubista E. Expression of estrogen receptors alpha and beta, progesterone receptor, co-activators and co-repressors in breast cancer. European Journal of Cancer, 38, Suppl. 3, S 54, 2002
Köstler WJ, Schwab B, Singer C, Neumann R, Marton E, Brodowicz T, Tomek S, Steger G, Wiltschke C, Krainer M, Zielinski CC. Serial monitoring of serum Her-2/neu extracellular domain (ECD) can predict response to trastuzumab-based therapy in patients with breast cancer, ASCO, Orlando, FL, 2002
Köstler WJ, Schwab B, Singer CF, Neumann R, Marton E, Brodowicz T, Tomek S, Steger G, Wiltschke C, Krainer M, Zielinski CC. Predictive value of serum Her-2/neu extracellular domain (ECD) during trastuzumab-based therapy in patients with breast cancer, AACR, San Francisco, CA, 2002
Hudelist G, Singer CF, Marton E, Czerwenka K, and Kubista E, Die Expression von Östrogenrezeptor alpha/beta, Progesteronrezeptor und Co-Faktoren beim Mammakarzinom. Kongress Menopause Andropause 2001, 11. Oct.-13. Oct. 2001, Vienna, Austria
Singer CF, Kronsteiner N, Marton E, Kubista M, Hirtenlehner K, Seifert M, Cullen K, and Kubista E. Die Genexpression von Matrix Metalloproteinasen im Brustkrebsstroma wird durch stromal-epitheliale Interaktionen differentiell reguliert. Gyn.-geb. Rundschau, 2001, 41 (2), 113
Koestler WJ, Schwab B, Singer CF, Neumann F, Tomek S, Flamm M, Steger G, Krainer M, Wiltschke C, Zielinski CC. Predictive value of serum Her-2/neu ECD during trastuzumab based therapy in patients with breast cancer XXIXth meeting of the International Society for Oncodevelopmental Biology and Medicine (ISOBM) and VIII International Symposium on the Biology and Clinical Usefulness of Tumor Markers, 29. Sept.-3. Oct 2001, Barcelona, Spain
Singer CF, Kronsteiner N, Marton E, Walter I, Kubista M, Czervenka K, Schreiber M, Seifert M, and Kubista E. (2001) Expression of the IL-1 system and sex steroid receptor mRNAs in human endometrial cancer, Europ. J. of Gyn. Oncol., Vol XXII, Suppl. 2001
Singer CF, Kronsteiner N, Marton E, Walter I, Kubista M, Czervenka K, Schreiber M, Seifert M, and Kubista E (2001) IL-1 system and sex steroid receptor gene expression in human endometrial cancer, Proc. 92nd Annual Meeting, AACR, Vol 42, March 2001
Singer CF, Kronsteiner N, Marton E, Kubista M, Hirtenlehner K, Seifert M, Cullen K, and Kubista E (2000) MMP-2 and MMP-9 Expression in Breast Cancer-Derived Human Fibroblasts is Differentially Regulated by Stromal-Epithelial Interactions. Europ. J. Cancer, 36, S 72, Suppl. 5
Singer CF, Kronsteiner N, Marton E, Kubista M, Hirtenlehner K, Seifert M, Cullen K, and Kubista E (2000) MMP-2 and MMP-9 Expression in Breast Cancer-Derived Human Fibroblasts is Differentially Regulated by Stromal-Epithelial Interactions. Acta Chir. Austriaca 32, Suppl. 163
Singer CF, Marbaix E, Lemoine P, Courtoy PJ, and Eeckhout Y. Local cytokines regulate the expression of selected matrix metalloproteinases but not of their tissue inhibitors in human endometrial fibroblasts. XXIIth FECTS Meeting, Patras, Greece, July 1-5, 2000
Singer CF, Kronsteiner N, Marton E, Kubista M, Hirtenlehner K, Seifert M, and Kubista E (2000) MMP-2 und MMP-9 expression in breast cancer-derived human fibroblasts is differentially regulated by stromal-epithelial interactions. Proceedings of the American Association of Cancer Research 41, 830
Singer CF, Kronsteiner N, Marton E, Kubista M, Hirtenlehner K, Seifert M, and Kubista E. MMP-2 und MMP-9 Expression in Brustkrebsstämmigen Fibroblasten wird von stromal-epithelialen Interaktionen differentiell reguliert. 8. Alpiner Workshop für Senologie, Corvara, Italy, March 18-25, 2000
Singer CF, Marbaix E, Kokorine I, Lemoine P, Donnez J, Eeckhout Y, and Courtoy P. Die IL-1mediierte parakrine Stimulation der endometrialen MMP-1 Expression wird durch Ovarielle Steroide doppelt gehemmt. Jahreshauptversammlung und wissenschaftliche Sitzung der Österreichischen Gesellschaft für Gynäkologie und Geburtshilfe, AKH Wien, Vienna, Austria, January 15th, 2000
Singer CF, Marbaix E, Kokorine I, Lemoine P, Donnez J, Eeckhout Y, and Courtoy P. Paracrine regulation of MMP-1 in the human endometrium and its dual block by ovarian steroids. European Research Conference on “Molecular Biology of Cellular Interactions”, Castelveccio Pascoli, Italy, Oct. 23 – 28, 1999
Singer C, Seifert M, Kubista E (1999) From Bench to Bedside: Innovative Therapiekonzepte zur Hemmung der lokalen Tumorinvasion. Acta Chirurgica Austriaca 31, Supp. 157, 14
Singer C, Hirtenlehner K, Kronsteiner N, Cullen KJ, Seifert M, and Kubista E (1999) Expression und Regulation von Matrix Metalloproteinasen im Mammakarzinom. Acta Chirurgica Austriaca 31, Supp. 157, 13-14
Singer CF, Marbaix E, Kokorine I, Lemoine P, Donnez J, Eeckhout Y, and Courtoy P (1999) Die Rolle von Zytokinen bei der Expression von interstitieller Kollagenase im menschlichen Endometrium. Gynäkologisch-geburtshilfl. Rundschau 39 (2), 97
Singer CF, Rasmussen A, Lippman ME, and Cullen KJ (1999) Breast cancer cells influence the pattern of cytokine expression in neighbouring breast fibroblasts via paracrine interactions. Eur. J. of Gyn. Onc. Vol. XX, 2, 122
Singer CF, Marbaix E, Kokorine I, Lemoine P, Donnez J, Eeckhout Y, and Courtoy P (1999) Parakrine Regulation von Matrix Metalloproteinasen (MMPs) im menschlichen Endometrium durch lokale Zytokine. Gynäkologisch-geburtshilfl. Rundschau 39 (1), 25-26
Singer CF, Marbaix E, Kokorine I, Lemoine P, Donnez J, Eeckhout Y, and Courtoy P (1998) 17ß-estradiol and progesterone suppress the IL-1-mediated interstitial collagenase (MMP-1) expression in human endometrium. Cell Biology International 22, 72-73
Singer CF, Marbaix E, Kokorine I, Lemoine P, Donnez J, Eeckhout Y, and Courtoy P (1997) Paracrine stimulation of interstitial collagenase (MMP-1) in the human endometrium by interleukin 1 and its dual block by ovarian steroids. 37th American Society for Cell Biology Annual Meeting, Washington, DC, USA, Dec. 13 - 17, 1997
Singer CF, Marbaix E, Kokorine I, Lemoine P, Donnez J, Eeckhout Y, and Courtoy P. (1997) Stimulation paracrine de la collagenase interstitielle (MMP-1) par l`interleukin-1 dans l`endometre humain et sa double inhibition par les steroides ovariens. Semaine scientifique "Les sciences de la vie" Brussels, Belgium, Oct. 20-25, 1997
Singer C, Rasmussen A, Lippman ME, and Cullen KJ (1996) Coexpression of IGF-II and ST-3 in fibroblasts from patients with breast cancer and sarcomas might indicate a reversion to a `fetal-type` behaviour of cells in a malignant tumor. XV FECTS meeting, Munich, Germany, August 5 - 10, 1996
Hornby A, Singer C, Rasmussen A, and Cullen KJ Stromal expression of growth factors in breast cancer. Second Keystone Symposion on Breast and Prostate Cancer, Lake Tahoe, CA, March 14-20, 1994
Minniti CP, O`Grady C, Cullen KJ, Helman LJ, and Singer C. Evidence for WT-1 expression in human rhabdomyosarcomas. Sixth Annual Meeting of the American Society of Pediatric Haematology - Oncology, Chicago, IL, USA September 30 - October 2, 1993
Singer CF, Smith HE, Lippman ME and Cullen KJ Distinct pattern of IGF-II and II gene expression in fibroblasts from specific locations in breast cancer patients. A result of clonal selection through paracrine interactions. American diabetes Association, 4th International symposion on Insulin, IGFs and their Receptors. Woods Hole, MA, April 20 - 23, 1993
Cullen KJ, Singer C, Allison A, Martire I, Lippman ME, and Smith S (1992) Stromal Growth Factor Expression and Function in Human Breast Cancer. J. of Cell. Biochem. 16D, CC014
Singer C, Smith HS, Lippman ME, and Cullen KJ (1992) IGF-I and IGF-II expression in fibroblasts derived from tumor, normal breast and skin of breast cancer patients. J. of Cell. Biochem. 16D, CC315